We have worked extensively with various tobacco companies around the world. Moreover, Dr. Kumaravel has conducted one of the major inter-laboratory trial on the Ames test for CORESTA in 2008.

• Toxicology of combustible and smokeless tobacco products
• Duty of care testing on cigarettes
• whole smoke and total particulate matter
• Additives and ingredients risk assessments
• Preclinical strategy recommendations
• Toxicology program design
• Clinical Research Organization (CRO) selection
• Contract management
• Project management
• Study protocol development and review
• Study monitoring on behalf of clients
• Report review and expert opinions
• Advice on disease models

Some of our peer reviewed publications in this area

1. Thorne D, Wilson J, Kumaravel TS, Massey ED, McEwan M. Measurement of oxidative DNA damage induced in cultured NCI-H292 human pulmonary carcinoma cells. Mutat Res. 2009 Feb 19;673(1):3-8
2. Delves, S. J., Faux, S. P., Jai, T. S., Kumaravel, T. S., Neilson, L. R., Meredith, C. (2008). Development of an EpiOral in vitro human tissue model for oral irritancy testing. Poster presented at the British Toxicology Society Annual Congress, Guildford, Surrey, UK, April 6-9, 2008.
3. Kumaravel TS, Vilhar B, Faux SP, Jha AN. Comet Assay measurements: a perspective. DOI: 10.1007/s10565-007-9043-9 Cell Biol Toxicology 2007.